Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor

The complement system plays a key role in innate immunity, inflammation, and coagulation. The system is delicately balanced by negative regulatory mechanisms that modulate the host response to pathogen invasion and injury. The serpin, C1-esterase inhibitor (C1-INH), is the only known plasma inhibito...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Wijeyewickrema, Lakshmi C., Lameignere, Emilie, Hor, Lilian, Duncan, Renee C., Shiba, Toshikazu, Travers, Richard J., Kapopara, Piyushkumar R., Lei, Victor, Smith, Stephanie A., Kim, Hugh, Morrissey, James H., Pike, Robert N., Conway, Edward M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2016
Ämnen:
Thrombosis and Hemostasis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043130/
https://ncbi.nlm.nih.gov/pubmed/27338096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-699561
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