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Polyphosphate is a cofactor for the activation of factor XI by thrombin

Factor XI deficiency is associated with a bleeding diathesis, but factor XII deficiency is not, indicating that, in normal hemostasis, factor XI must be activated in vivo by a protease other than factor XIIa. Several groups have identified thrombin as the most likely activator of factor XI, although...

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Bibliografski detalji
Glavni autori: Choi, Sharon H., Smith, Stephanie A., Morrissey, James H.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245215/
https://ncbi.nlm.nih.gov/pubmed/21976677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368811
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