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Polyphosphate is a cofactor for the activation of factor XI by thrombin
Factor XI deficiency is associated with a bleeding diathesis, but factor XII deficiency is not, indicating that, in normal hemostasis, factor XI must be activated in vivo by a protease other than factor XIIa. Several groups have identified thrombin as the most likely activator of factor XI, although...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3245215/ https://ncbi.nlm.nih.gov/pubmed/21976677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368811 |
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