The dimeric structure of factor XI and zymogen activation

Factor XI (fXI) is a homodimeric zymogen that is converted to a protease with 1 (1/2-fXIa) or 2 (fXIa) active subunits by factor XIIa (fXIIa) or thrombin. It has been proposed that the dimeric structure is required for normal fXI activation. Consistent with this premise, fXI monomers do not reconsti...

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Detalhes bibliográficos
Main Authors: Geng, Yipeng, Verhamme, Ingrid M., Smith, Stephen B., Sun, Mao-fu, Matafonov, Anton, Cheng, Qiufang, Smith, Stephanie A., Morrissey, James H., Gailani, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650707/
https://ncbi.nlm.nih.gov/pubmed/23515926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-473629
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