Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

When blood is exposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the proteases αFXIIa and α-kallikrein by a process called contact activation. These enzymes contribute to host-defense...

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Udgivet i:Blood
Main Authors: Ivanov, Ivan, Matafonov, Anton, Sun, Mao-fu, Cheng, Qiufang, Dickeson, S. Kent, Verhamme, Ingrid M., Emsley, Jonas, Gailani, David
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356457/
https://ncbi.nlm.nih.gov/pubmed/28069606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-744110
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