The dimeric structure of factor XI and zymogen activation

Factor XI (fXI) is a homodimeric zymogen that is converted to a protease with 1 (1/2-fXIa) or 2 (fXIa) active subunits by factor XIIa (fXIIa) or thrombin. It has been proposed that the dimeric structure is required for normal fXI activation. Consistent with this premise, fXI monomers do not reconsti...

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Detaylı Bibliyografya
Asıl Yazarlar: Geng, Yipeng, Verhamme, Ingrid M., Smith, Stephen B., Sun, Mao-fu, Matafonov, Anton, Cheng, Qiufang, Smith, Stephanie A., Morrissey, James H., Gailani, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2013
Konular:
Thrombosis and Hemostasis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650707/
https://ncbi.nlm.nih.gov/pubmed/23515926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-473629
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