FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow

Factor XIIa (FXIIa) and factor XIa (FXIa) contribute to thrombosis in animal models, whereas platelet-derived polyphosphate (polyP) may potentiate contact or thrombin-feedback pathways. The significance of these mediators in human blood under thrombotic flow conditions on tissue factor (TF) –bearing...

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Vydáno v:Blood
Hlavní autoři: Zhu, Shu, Travers, Richard J., Morrissey, James H., Diamond, Scott L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2015
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573872/
https://ncbi.nlm.nih.gov/pubmed/26136249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-641472
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