Polyphosphate exerts differential effects on blood clotting, depending on polymer size

Polyphosphate, a linear polymer of inorganic phosphate, is secreted by activated platelets and accumulates in many infectious microorganisms. We recently showed that polyphosphate modulates the blood coagulation cascade at 3 steps: it triggers the contact pathway, it accelerates factor V activation,...

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Hlavní autoři: Smith, Stephanie A., Choi, Sharon H., Davis-Harrison, Rebecca, Huyck, Jillian, Boettcher, John, Reinstra, Chad M., Morrissey, James H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993633/
https://ncbi.nlm.nih.gov/pubmed/20709905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-266791
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