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Generation of VDR Knock-Out Mice via Zygote Injection of CRISPR/Cas9 System
CRISPR/Cas9 system has become a new versatile technology for genome engineering in various species. To achieve targeted modifications at the same site in both human and mice genomes by a CRISPR/Cas9 nuclease, we designed two target sites in conserved regions of vitamin D receptor (VDR) gene, which c...
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| Опубликовано в: : | PLoS One |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5042489/ https://ncbi.nlm.nih.gov/pubmed/27685656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163551 |
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