Multi-Center Evaluation of the Fully Automated PCR-Based Idylla(™) KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer

Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent in colorectal cancer are KRAS exon 2 mutations (40% prevalence); lower prevalen...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Solassol, Jérôme, Vendrell, Julie, Märkl, Bruno, Haas, Christian, Bellosillo, Beatriz, Montagut, Clara, Smith, Matthew, O’Sullivan, Brendan, D’Haene, Nicky, Le Mercier, Marie, Grauslund, Morten, Melchior, Linea Cecilie, Burt, Emma, Cotter, Finbarr, Stieber, Daniel, Schmitt, Fernando de Lander, Motta, Valentina, Lauricella, Calogero, Colling, Richard, Soilleux, Elizabeth, Fassan, Matteo, Mescoli, Claudia, Collin, Christine, Pagès, Jean-Christophe, Sillekens, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042411/
https://ncbi.nlm.nih.gov/pubmed/27685259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163444
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