Concomitant occurrence of EGFR (epidermal growth factor receptor) and KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) mutations in an ALK (anaplastic lymphoma kinase)-positive lung adenocarcinoma patient with acquired resistance to crizotinib: a case report

BACKGROUND: Anaplastic lymphoma kinase-positive non-small cell lung carcinoma patients are generally highly responsive to the dual anaplastic lymphoma kinase and MET tyrosine kinase inhibitor crizotinib. However, they eventually acquire resistance to this drug, preventing the anaplastic lymphoma kin...

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Detalhes bibliográficos
Main Authors: Rossing, Henrik H, Grauslund, Morten, Urbanska, Edyta M, Melchior, Linea C, Rask, Charlotte K, Costa, Junia C, Skov, Birgit G, Sørensen, Jens Benn, Santoni-Rugiu, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879082/
https://ncbi.nlm.nih.gov/pubmed/24279718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-6-489
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