Intrinsic Resistance to EGFR-Tyrosine Kinase Inhibitors in EGFR-Mutant Non-Small Cell Lung Cancer: Differences and Similarities with Acquired Resistance

Activating mutations in the epidermal growth factor receptor gene occur as early cancer-driving clonal events in a subset of patients with non-small cell lung cancer (NSCLC) and result in increased sensitivity to EGFR-tyrosine-kinase-inhibitors (EGFR-TKIs). Despite very frequent and often prolonged...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Santoni-Rugiu, Eric, Melchior, Linea C., Urbanska, Edyta M., Jakobsen, Jan N., de Stricker, Karin, Grauslund, Morten, Sørensen, Jens B.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6678669/
https://ncbi.nlm.nih.gov/pubmed/31266248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11070923
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