Characterization of acquired receptor tyrosine–kinase fusions as mechanisms of resistance to EGFR tyrosine–kinase inhibitors

Purpose: Responses to EGFR-targeted therapy are generally temporary, due to inevitable drug resistance. The prevalence and characteristics of receptor tyrosine–kinase (RTK) fusion as acquired resistance to EGFR tyrosine–kinase inhibitors (TKIs) are rarely investigated. Methods: We retrospectively re...

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Detalhes bibliográficos
Publicado no:Cancer Manag Res
Main Authors: Xu, Haiyuan, Shen, Jinge, Xiang, Jianxing, Li, Haiyan, Li, Bing, Zhang, Tengfei, Zhang, Lu, Mao, Xinru, Jian, Hong, Shu, Yongqian
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628603/
https://ncbi.nlm.nih.gov/pubmed/31372039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S197337
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