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Redundant kinase activation and resistance of EGFR-tyrosine kinase inhibitors

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown dramatic effects against that tumors harboring EGFR activating mutations in the EGFR intracytoplasmic tyrosine kinase domain and resulted in cell apoptosis. Unfortunately, a number of patients ultimately developed r...

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Bibliografiske detaljer
Udgivet i:Am J Cancer Res
Main Authors: Luo, Min, Fu, Li-Wu
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4266699/
https://ncbi.nlm.nih.gov/pubmed/25520855
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