Host-dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors

Lung cancers driven by mutant forms of the epidermal growth factor receptor (EGFR) invariably develop resistance to kinase inhibitors, often due to secondary mutations. Here we describe an unconventional mechanism of resistance to dacomitinib, a newly approved covalent EGFR kinase inhibitor, and unc...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Haga, Yuya, Marrocco, Ilaria, Noronha, Ashish, Uribe, Mary Luz, Nataraj, Nishanth Belugali, Sekar, Arunachalam, Drago-Garcia, Diana, Borgoni, Simone, Lindzen, Moshit, Giri, Suvendu, Wiemann, Stefan, Tsutsumi, Yasuo, Yarden, Yosef
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611293/
https://ncbi.nlm.nih.gov/pubmed/33941614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-3555
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