Multi-Center Evaluation of the Fully Automated PCR-Based Idylla(™) KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer

Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent in colorectal cancer are KRAS exon 2 mutations (40% prevalence); lower prevalen...

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Publicado en:PLoS One
Autores principales: Solassol, Jérôme, Vendrell, Julie, Märkl, Bruno, Haas, Christian, Bellosillo, Beatriz, Montagut, Clara, Smith, Matthew, O’Sullivan, Brendan, D’Haene, Nicky, Le Mercier, Marie, Grauslund, Morten, Melchior, Linea Cecilie, Burt, Emma, Cotter, Finbarr, Stieber, Daniel, Schmitt, Fernando de Lander, Motta, Valentina, Lauricella, Calogero, Colling, Richard, Soilleux, Elizabeth, Fassan, Matteo, Mescoli, Claudia, Collin, Christine, Pagès, Jean-Christophe, Sillekens, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042411/
https://ncbi.nlm.nih.gov/pubmed/27685259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163444
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