Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model

α-Synuclein (α-Syn) is a key protein that accumulates as hyperphosphorylated aggregates in pathologic hallmark features of Parkinson's disease (PD) and other neurodegenerative disorders. Phosphorylation of this protein at serine 129 is believed to promote its aggregation and neurotoxicity, sugg...

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Publicado no:J Neurosci
Main Authors: Lee, Kang-Woo, Chen, Walter, Junn, Eunsung, Im, Joo-Young, Grosso, Hilary, Sonsalla, Patricia K., Feng, Xuyan, Ray, Neelanjana, Fernandez, Jose R., Chao, Yang, Masliah, Eliezer, Voronkov, Michael, Braithwaite, Steven P., Stock, Jeffry B., Mouradian, M. Maral
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038983/
https://ncbi.nlm.nih.gov/pubmed/21562258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6513-10.2011
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