Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeast

α-Synuclein is a key pathogenic protein that aggregates in hallmark lesions in Parkinson's disease and other α-synucleinopathies. Prior in vitro studies demonstrated that it is a substrate for cross-linking by transglutaminase 2 (TG2) into higher-order species. Here we investigated whether this...

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Autori principali: Grosso, Hilary, Woo, Jong-Min, Lee, Kang-Woo, Im, Joo-Young, Masliah, Eliezer, Junn, Eunsung, Mouradian, M. Maral
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4202112/
https://ncbi.nlm.nih.gov/pubmed/24970392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-251413
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