Repression of α-synuclein expression and toxicity by microRNA-7

α-Synuclein is a key protein in Parkinson's disease (PD) because it accumulates as fibrillar aggregates in pathologic hallmark features in affected brain regions, most notably in nigral dopaminergic neurons. Intraneuronal levels of this protein appear critical in mediating its toxicity, because...

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Dettagli Bibliografici
Autori principali: Junn, Eunsung, Lee, Kang-Woo, Jeong, Byeong Seon, Chan, Teresa W., Im, Joo-Young, Mouradian, M. Maral
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722353/
https://ncbi.nlm.nih.gov/pubmed/19628698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906277106
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