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Apoptosis Signal Regulating Kinase 1 Modulates the Phenotype of α-Synuclein Transgenic Mice
α-Synuclein is a key pathogenic protein in α-synucleinopathies including Parkinson’s disease (PD), and its over-expression and aggregation in model systems are associated with a neuroinflammatory response and increased oxidative stress. Apoptosis signal-regulating kinase 1 (ASK1) is activated upon s...
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| Publicado no: | Neurobiol Aging |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4268347/ https://ncbi.nlm.nih.gov/pubmed/25219466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.07.034 |
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