Apoptosis Signal Regulating Kinase 1 Modulates the Phenotype of α-Synuclein Transgenic Mice

α-Synuclein is a key pathogenic protein in α-synucleinopathies including Parkinson’s disease (PD), and its over-expression and aggregation in model systems are associated with a neuroinflammatory response and increased oxidative stress. Apoptosis signal-regulating kinase 1 (ASK1) is activated upon s...

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Foilsithe in:Neurobiol Aging
Main Authors: Lee, Kang-Woo, Woo, Jong-Min, Im, Joo-Young, Park, Eun S., He, Liqiang, Ichijo, Hidenori, Junn, Eunsung, Mouradian, M. Maral
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268347/
https://ncbi.nlm.nih.gov/pubmed/25219466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.07.034
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