Apoptosis Signal-Regulating Kinase 1 Mediates MPTP Toxicity and Regulates Glial Activation

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase 3 family, is activated by oxidative stress. The death-signaling pathway mediated by ASK1 is inhibited by DJ-1, which is linked to recessively inherited Parkinson's disease (PD). Considering that DJ-1 d...

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Autori principali: Lee, Kang-Woo, Zhao, Xin, Im, Joo-Young, Grosso, Hilary, Jang, Won Hee, Chan, Teresa W., Sonsalla, Patricia K., German, Dwight C., Ichijo, Hidenori, Junn, Eunsung, Mouradian, M. Maral
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254627/
https://ncbi.nlm.nih.gov/pubmed/22253830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029935
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