Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model

α-Synuclein (α-Syn) is a key protein that accumulates as hyperphosphorylated aggregates in pathologic hallmark features of Parkinson's disease (PD) and other neurodegenerative disorders. Phosphorylation of this protein at serine 129 is believed to promote its aggregation and neurotoxicity, sugg...

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Udgivet i:J Neurosci
Main Authors: Lee, Kang-Woo, Chen, Walter, Junn, Eunsung, Im, Joo-Young, Grosso, Hilary, Sonsalla, Patricia K., Feng, Xuyan, Ray, Neelanjana, Fernandez, Jose R., Chao, Yang, Masliah, Eliezer, Voronkov, Michael, Braithwaite, Steven P., Stock, Jeffry B., Mouradian, M. Maral
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038983/
https://ncbi.nlm.nih.gov/pubmed/21562258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6513-10.2011
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