Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model

α-Synuclein (α-Syn) is a key protein that accumulates as hyperphosphorylated aggregates in pathologic hallmark features of Parkinson's disease (PD) and other neurodegenerative disorders. Phosphorylation of this protein at serine 129 is believed to promote its aggregation and neurotoxicity, sugg...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Lee, Kang-Woo, Chen, Walter, Junn, Eunsung, Im, Joo-Young, Grosso, Hilary, Sonsalla, Patricia K., Feng, Xuyan, Ray, Neelanjana, Fernandez, Jose R., Chao, Yang, Masliah, Eliezer, Voronkov, Michael, Braithwaite, Steven P., Stock, Jeffry B., Mouradian, M. Maral
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038983/
https://ncbi.nlm.nih.gov/pubmed/21562258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6513-10.2011
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