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Poor immunogenicity of a self/tumor antigen derives from peptide–MHC-I instability and is independent of tolerance
Understanding the mechanisms underlying the poor immunogenicity of human self/tumor antigens is challenging because of experimental limitations in humans. Here, we developed a human-mouse chimeric model that allows us to investigate the roles of the frequency and self-reactivity of antigen-specific...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
2004
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC503773/ https://ncbi.nlm.nih.gov/pubmed/15314692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421695 |
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