Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8(+) T Cells

Many tumor-associated antigens are derived from nonmutated “self” proteins. T cells infiltrating tumor deposits recognize self-antigens presented by tumor cells and can be expanded in vivo with vaccination. These T cells exist in a functionally tolerant state, as they rarely result in tumor eradicat...

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Main Authors: Overwijk, Willem W., Theoret, Marc R., Finkelstein, Steven E., Surman, Deborah R., de Jong, Laurina A., Vyth-Dreese, Florry A., Dellemijn, Trees A., Antony, Paul A., Spiess, Paul J., Palmer, Douglas C., Heimann, David M., Klebanoff, Christopher A., Yu, Zhiya, Hwang, Leroy N., Feigenbaum, Lionel, Kruisbeek, Ada M., Rosenberg, Steven A., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194177/
https://ncbi.nlm.nih.gov/pubmed/12925674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030590
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