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Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8(+) T Cells
Many tumor-associated antigens are derived from nonmutated “self” proteins. T cells infiltrating tumor deposits recognize self-antigens presented by tumor cells and can be expanded in vivo with vaccination. These T cells exist in a functionally tolerant state, as they rarely result in tumor eradicat...
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| Autori principali: | , , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2194177/ https://ncbi.nlm.nih.gov/pubmed/12925674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030590 |
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