CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4 T helper cells and hindered by naturally occurring T regulatory cells.

CD4(+) T cells control the effector function, memory, and maintenance of CD8(+) T cells. Paradoxically, we found that absence of CD4(+) T cells enhanced adoptive immunotherapy of cancer when using CD8(+) T cells directed against a persisting tumor/self-antigen. However, adoptive transfer of CD4(+)CD...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Antony, Paul A., Piccirillo, Ciriaco A., Akpinarli, Akgül, Finkelstein, Steven E., Speiss, Paul J., Surman, Deborah R., Palmer, Douglas C., Chan, Chi-Chao, Klebanoff, Christopher A., Overwijk, Willem W., Rosenberg, Steven A., Restifo, Nicholas P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2005
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1403291/
https://ncbi.nlm.nih.gov/pubmed/15728465
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