IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8(+) T Cells

IL-15 and IL-2 possess similar properties, including the ability to induce T cell proliferation. However, whereas IL-2 can promote apoptosis and limit CD8(+) memory T cell survival and proliferation, IL-15 helps maintain a memory CD8(+) T cell population and can inhibit apoptosis. We sought to deter...

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Detalhes bibliográficos
Main Authors: Klebanoff, Christopher A., Finkelstein, Steven E., Surman, Deborah R., Lichtman, Michael K., Gattinoni, Luca, Theoret, Marc R., Grewal, Navrose, Spiess, Paul J., Antony, Paul A., Palmer, Douglas C., Tagaya, Yutaka, Rosenberg, Steven A., Waldmann, Thomas A., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC357036/
https://ncbi.nlm.nih.gov/pubmed/14762166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307298101
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