CTLA-4 dysregulation of self/tumor-reactive CD8(+) T-cell function is CD4(+) T-cell dependent

Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) maintains peripheral tolerance by suppressing T-cell activation and proliferation but its precise role in vivo remains unclear. We sought to elucidate the impact of CTLA-4 expression on self/tumor-reactive CD8(+) T cells by using the glycoprotein...

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Detalhes bibliográficos
Main Authors: Gattinoni, Luca, Ranganathan, Anju, Surman, Deborah R., Palmer, Douglas C., Antony, Paul A., Theoret, Marc R., Heimann, David M., Rosenberg, Steven A., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679662/
https://ncbi.nlm.nih.gov/pubmed/16882704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-034066
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