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CTLA-4 dysregulation of self/tumor-reactive CD8(+) T-cell function is CD4(+) T-cell dependent
Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) maintains peripheral tolerance by suppressing T-cell activation and proliferation but its precise role in vivo remains unclear. We sought to elucidate the impact of CTLA-4 expression on self/tumor-reactive CD8(+) T cells by using the glycoprotein...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The American Society of Hematology
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1679662/ https://ncbi.nlm.nih.gov/pubmed/16882704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-07-034066 |
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