Programming tumor-reactive effector memory CD8(+) T cells in vitro obviates the requirement for in vivo vaccination

Naive and memory CD8(+) T cells can undergo programmed activation and expansion in response to a short T-cell receptor stimulus, but the extent to which in vitro programming can qualitatively substitute for an in vivo antigen stimulation remains unknown. We show that self-/tumor-reactive effector me...

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Bibliographic Details
Main Authors: Klebanoff, Christopher A., Yu, Zhiya, Hwang, Leroy N., Palmer, Douglas C., Gattinoni, Luca, Restifo, Nicholas P.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738567/
https://ncbi.nlm.nih.gov/pubmed/19561320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-192419
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