Wnt signaling arrests effector T cell differentiation and generates CD8(+) memory stem cells

Self-renewing cell populations such as hematopoietic stem cells and memory B and T lymphocytes might be regulated by shared signaling pathways1. Wnt/β-catenin is an evolutionarily conserved pathway that promotes hematopoietic stem cell self-renewal and multipotency by limiting stem cell proliferatio...

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Detalhes bibliográficos
Main Authors: Gattinoni, Luca, Zhong, Xiao-Song, Palmer, Douglas C, Ji, Yun, Hinrichs, Christian S, Yu, Zhiya, Wrzesinski, Claudia, Boni, Andrea, Cassard, Lydie, Church, Lindsay, Paulos, Chrystal M, Muranski, Pawel, Restifo, Nicholas P
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707501/
https://ncbi.nlm.nih.gov/pubmed/19525962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1982
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