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IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8(+) T Cells

IL-15 and IL-2 possess similar properties, including the ability to induce T cell proliferation. However, whereas IL-2 can promote apoptosis and limit CD8(+) memory T cell survival and proliferation, IL-15 helps maintain a memory CD8(+) T cell population and can inhibit apoptosis. We sought to deter...

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Autori principali: Klebanoff, Christopher A., Finkelstein, Steven E., Surman, Deborah R., Lichtman, Michael K., Gattinoni, Luca, Theoret, Marc R., Grewal, Navrose, Spiess, Paul J., Antony, Paul A., Palmer, Douglas C., Tagaya, Yutaka, Rosenberg, Steven A., Waldmann, Thomas A., Restifo, Nicholas P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC357036/
https://ncbi.nlm.nih.gov/pubmed/14762166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307298101
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