Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains

Functional topography of rat class I major histocompatibility complex (MHC) molecule was studied. The α(1)-helical sequences that are shared by class I RT1.Al and RT1.A(u) were substituted in the RT1.A(a) molecule to produce the composite [α(1h)(l/u)]-RT1.A(a) MHC class I allochimeric molecule. Domi...

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Main Authors: Semiletova, Natalya V., Shen, Xiu-Da, Feldman, Daniel M., Gao, Feng, Mhoyan, Ana, Liu, Dhai, Busuttil, Ronald W., Kupiec-Weglinski, Jerzy W., Ghobrial, Rafik M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699404/
https://ncbi.nlm.nih.gov/pubmed/17936255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2007.04.008
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