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Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains
Functional topography of rat class I major histocompatibility complex (MHC) molecule was studied. The α(1)-helical sequences that are shared by class I RT1.Al and RT1.A(u) were substituted in the RT1.A(a) molecule to produce the composite [α(1h)(l/u)]-RT1.A(a) MHC class I allochimeric molecule. Domi...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3699404/ https://ncbi.nlm.nih.gov/pubmed/17936255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2007.04.008 |
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