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Poor immunogenicity of a self/tumor antigen derives from peptide–MHC-I instability and is independent of tolerance

Understanding the mechanisms underlying the poor immunogenicity of human self/tumor antigens is challenging because of experimental limitations in humans. Here, we developed a human-mouse chimeric model that allows us to investigate the roles of the frequency and self-reactivity of antigen-specific...

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Detalhes bibliográficos
Main Authors: Yu, Zhiya, Theoret, Marc R., Touloukian, Christopher E., Surman, Deborah R., Garman, Scott C., Feigenbaum, Lionel, Baxter, Tiffany K., Baker, Brian M., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC503773/
https://ncbi.nlm.nih.gov/pubmed/15314692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421695
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