Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib

Metabolic activation of the dual-tyrosine kinase inhibitor lapatinib by cytochromes CYP3A4 and CYP3A5 has been implicated in lapatinib-induced idiosyncratic hepatotoxicity; however, the relative enzyme contributions have not been established. The objective of this study was to examine the roles of C...

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Bibliografiske detaljer
Udgivet i:Drug Metab Dispos
Main Authors: Towles, Joanna K., Clark, Rebecca N., Wahlin, Michelle D., Uttamsingh, Vinita, Rettie, Allan E., Jackson, Klarissa D.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034700/
https://ncbi.nlm.nih.gov/pubmed/27450182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.070839
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