Laddar...
Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib
O-Dealkylation of the tyrosine kinase inhibitor lapatinib by cytochrome P450 3A enzymes is implicated in the development of lapatinib-induced hepatotoxicity. Conjugative metabolism of debenzylated lapatinib (M1) via glucuronidation and sulfation is thought to be a major detoxication pathway for lapa...
Sparad:
| I publikationen: | Drug Metab Dispos |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
The American Society for Pharmacology and Experimental Therapeutics
2021
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7883098/ https://ncbi.nlm.nih.gov/pubmed/33376146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000236 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|