ロード中...
Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib
O-Dealkylation of the tyrosine kinase inhibitor lapatinib by cytochrome P450 3A enzymes is implicated in the development of lapatinib-induced hepatotoxicity. Conjugative metabolism of debenzylated lapatinib (M1) via glucuronidation and sulfation is thought to be a major detoxication pathway for lapa...
保存先:
| 出版年: | Drug Metab Dispos |
|---|---|
| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Pharmacology and Experimental Therapeutics
2021
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7883098/ https://ncbi.nlm.nih.gov/pubmed/33376146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000236 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|