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Interindividual Variation in CYP3A Activity Influences Lapatinib Bioactivation
Lapatinib is a dual tyrosine kinase inhibitor associated with rare but potentially severe idiosyncratic hepatotoxicity. We have previously shown that cytochromes P450 CYP3A4 and CYP3A5 quantitatively contribute to lapatinib bioactivation, leading to formation of a reactive, potentially toxic quinone...
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| Publicado no: | Drug Metab Dispos |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6815940/ https://ncbi.nlm.nih.gov/pubmed/31492693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.088823 |
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