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Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib
Mechanism-based inactivation (MBI) of CYP450 enzymes is a unique form of inhibition in which the enzymatic machinery of the victim is responsible for generation of the reactive metabolite. This precondition sets up a time-dependency for the inactivation process, a hallmark feature that characterizes...
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| Publicado en: | Drug Metab Rev |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4661142/ https://ncbi.nlm.nih.gov/pubmed/25639891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/03602532.2014.1003648 |
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