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Acetylenes: cytochrome P450 oxidation and mechanism-based enzyme inactivation
The oxidation of carbon-carbon triple bonds by cytochrome P450 produces ketene metabolites that are hydrolyzed to acetic acid derivatives or are trapped by nucleophiles. In the special case of 17α-ethynyl sterols, D-ring expansion and de-ethynylation have been observed as competing pathways. The oxi...
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| Gepubliceerd in: | Drug Metab Rev |
|---|---|
| Hoofdauteur: | |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6699906/ https://ncbi.nlm.nih.gov/pubmed/31203694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03602532.2019.1632891 |
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