Chargement en cours...
Acetylenes: cytochrome P450 oxidation and mechanism-based enzyme inactivation
The oxidation of carbon-carbon triple bonds by cytochrome P450 produces ketene metabolites that are hydrolyzed to acetic acid derivatives or are trapped by nucleophiles. In the special case of 17α-ethynyl sterols, D-ring expansion and de-ethynylation have been observed as competing pathways. The oxi...
Enregistré dans:
| Publié dans: | Drug Metab Rev |
|---|---|
| Auteur principal: | |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6699906/ https://ncbi.nlm.nih.gov/pubmed/31203694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/03602532.2019.1632891 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|