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Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib
Metabolic activation of the dual-tyrosine kinase inhibitor lapatinib by cytochromes CYP3A4 and CYP3A5 has been implicated in lapatinib-induced idiosyncratic hepatotoxicity; however, the relative enzyme contributions have not been established. The objective of this study was to examine the roles of C...
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| Publicado no: | Drug Metab Dispos |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5034700/ https://ncbi.nlm.nih.gov/pubmed/27450182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.070839 |
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