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Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib
Lapatinib, an oral breast cancer drug, has recently been reported to be a mechanism-based inactivator of cytochrome P450 (P450) 3A4 and also an idiosyncratic hepatotoxicant. It was suggested that formation of a reactive quinoneimine metabolite was involved in mechanism-based inactivation (MBI) and/o...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100900/ https://ncbi.nlm.nih.gov/pubmed/21363997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.037531 |
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