Interindividual Variation in CYP3A Activity Influences Lapatinib Bioactivation

Lapatinib is a dual tyrosine kinase inhibitor associated with rare but potentially severe idiosyncratic hepatotoxicity. We have previously shown that cytochromes P450 CYP3A4 and CYP3A5 quantitatively contribute to lapatinib bioactivation, leading to formation of a reactive, potentially toxic quinone...

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Bibliographic Details
Published in:Drug Metab Dispos
Main Authors: Bissada, Jennifer E., Truong, Vivian, Abouda, Arsany A., Wines, Kahari J., Crouch, Rachel D., Jackson, Klarissa D.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815940/
https://ncbi.nlm.nih.gov/pubmed/31492693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.088823
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