Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study

Objective. IFN α Kinoid (IFN-K) is a therapeutic vaccine composed of IFNα2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples from SLE patients. Here, we analysed extended follow-up...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Ducreux, Julie, Houssiau, Frédéric A., Vandepapelière, Pierre, Jorgensen, Christian, Lazaro, Estibaliz, Spertini, François, Colaone, Fabien, Roucairol, Camille, Laborie, Marion, Croughs, Thérèse, Grouard-Vogel, Géraldine, Lauwerys, Bernard R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034220/
https://ncbi.nlm.nih.gov/pubmed/27354683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kew262
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