TNFα kinoid vaccination-induced neutralizing antibodies to TNFα protect mice from autologous TNFα-driven chronic and acute inflammation

The proinflammatory cytokine TNFα is a potent mediator of septic shock and a therapeutic target for chronic inflammatory pathologies including rheumatoid arthritis and Crohn's disease. As an alternative to anti-human TNFα (hTNFα) mAbs and other hTNFα blocker approved drugs, we developed an acti...

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Bibliographische Detailangaben
Hauptverfasser: Le Buanec, Hélène, Delavallée, Laure, Bessis, Natacha, Paturance, Sébastien, Bizzini, Bernard, Gallo, Robert, Zagury, Daniel, Boissier, Marie-Christophe
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748245/
https://ncbi.nlm.nih.gov/pubmed/17158801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604827103
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