Protection from articular damage by passive or active anti-tumour necrosis factor (TNF)-α immunotherapy in human TNF-α transgenic mice depends on anti-TNF-α antibody levels

Active anti-tumour necrosis factor (TNF)-α immunization with the kinoid of TNF-α (TNF-K) induces polyclonal anti-TNF-α antibodies and ameliorates arthritis in human TNF-α (hTNF-α) transgenic mice (TTg). We compared the efficacy of TNF-K to that of infliximab (IFX) and of TNF-K and IFX co-administrat...

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Detalhes bibliográficos
Main Authors: Semerano, L, Biton, J, Delavallée, L, Duvallet, E, Assier, E, Bessis, N, Bernier, E, Dhellin, O, Grouard-Vogel, G, Boissier, M-C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719931/
https://ncbi.nlm.nih.gov/pubmed/23480185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12040
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