Therapeutic Vaccination with TNF-Kinoid in TNF Antagonist-Resistant Rheumatoid Arthritis: A Phase II Randomized, Controlled Clinical Trial

OBJECTIVES: Active immunization, or vaccination, with tumor necrosis factor (TNF)-Kinoid (TNF-K) is a novel approach to induce polyclonal anti-TNF antibodies in immune-mediated inflammatory diseases. This study was performed to transfer the proof of concept obtained in mice model of rheumatoid arthr...

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Pubblicato in:PLoS One
Autori principali: Durez, Patrick, Vandepapeliere, Pierre, Miranda, Pedro, Toncheva, Antoaneta, Berman, Alberto, Kehler, Tatjana, Mociran, Eugenia, Fautrel, Bruno, Mariette, Xavier, Dhellin, Olivier, Fanget, Bernard, Ouary, Stephane, Grouard-Vogel, Géraldine, Boissier, Marie-Christophe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269456/
https://ncbi.nlm.nih.gov/pubmed/25517733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113465
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