Higher expression of TNFα-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy

BACKGROUND: IL6-related T cell activation and TNFα-dependent cell proliferation are major targets of therapy in the RA synovium. We investigated whether expression of these pathways in RA synovial biopsies is associated with disease activity and response to therapy. METHOD: Correlation and gene set...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: De Groof, Aurélie, Ducreux, Julie, Humby, Frances, Nzeusseu Toukap, Adrien, Badot, Valérie, Pitzalis, Costantino, Houssiau, Frédéric A., Durez, Patrick, Lauwerys, Bernard R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719339/
https://ncbi.nlm.nih.gov/pubmed/26792343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-0919-z
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