Paneth cell defects in Crohn’s disease patients promote dysbiosis

BACKGROUND. Paneth cell dysfunction has been implicated in a subset of Crohn’s disease (CD) patients. We previously stratified clinical outcomes of CD patients by using Paneth cell phenotypes, which we defined by the intracellular distribution of antimicrobial proteins. Animal studies suggest that P...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Liu, Ta-Chiang, Gurram, Bhaskar, Baldridge, Megan T., Head, Richard, Lam, Vy, Luo, Chengwei, Cao, Yumei, Simpson, Pippa, Hayward, Michael, Holtz, Mary L., Bousounis, Pavlos, Noe, Joshua, Lerner, Diana, Cabrera, Jose, Biank, Vincent, Stephens, Michael, Huttenhower, Curtis, McGovern, Dermot P.B., Xavier, Ramnik J., Stappenbeck, Thaddeus S., Salzman, Nita H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Clinical Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033844/
https://ncbi.nlm.nih.gov/pubmed/27699268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86907
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