Paneth cell defects in Crohn’s disease patients promote dysbiosis

BACKGROUND. Paneth cell dysfunction has been implicated in a subset of Crohn’s disease (CD) patients. We previously stratified clinical outcomes of CD patients by using Paneth cell phenotypes, which we defined by the intracellular distribution of antimicrobial proteins. Animal studies suggest that P...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Liu, Ta-Chiang, Gurram, Bhaskar, Baldridge, Megan T., Head, Richard, Lam, Vy, Luo, Chengwei, Cao, Yumei, Simpson, Pippa, Hayward, Michael, Holtz, Mary L., Bousounis, Pavlos, Noe, Joshua, Lerner, Diana, Cabrera, Jose, Biank, Vincent, Stephens, Michael, Huttenhower, Curtis, McGovern, Dermot P.B., Xavier, Ramnik J., Stappenbeck, Thaddeus S., Salzman, Nita H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033844/
https://ncbi.nlm.nih.gov/pubmed/27699268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86907
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