Paneth cell defects in Crohn’s disease patients promote dysbiosis

BACKGROUND. Paneth cell dysfunction has been implicated in a subset of Crohn’s disease (CD) patients. We previously stratified clinical outcomes of CD patients by using Paneth cell phenotypes, which we defined by the intracellular distribution of antimicrobial proteins. Animal studies suggest that P...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Liu, Ta-Chiang, Gurram, Bhaskar, Baldridge, Megan T., Head, Richard, Lam, Vy, Luo, Chengwei, Cao, Yumei, Simpson, Pippa, Hayward, Michael, Holtz, Mary L., Bousounis, Pavlos, Noe, Joshua, Lerner, Diana, Cabrera, Jose, Biank, Vincent, Stephens, Michael, Huttenhower, Curtis, McGovern, Dermot P.B., Xavier, Ramnik J., Stappenbeck, Thaddeus S., Salzman, Nita H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033844/
https://ncbi.nlm.nih.gov/pubmed/27699268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86907
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