Interaction between smoking and ATG16L1(T300A) triggers Paneth cell defects in Crohn’s disease

It is suggested that subtyping of complex inflammatory diseases can be based on genetic susceptibility and relevant environmental exposure (G+E). We propose that using matched cellular phenotypes in human subjects and corresponding preclinical models with the same G+E combinations is useful to this...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Liu, Ta-Chiang, Kern, Justin T., VanDussen, Kelli L., Xiong, Shanshan, Kaiko, Gerard E., Wilen, Craig B., Rajala, Michael W., Caruso, Roberta, Holtzman, Michael J., Gao, Feng, McGovern, Dermot P.B., Nunez, Gabriel, Head, Richard D., Stappenbeck, Thaddeus S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205411/
https://ncbi.nlm.nih.gov/pubmed/30137026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120453
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