Interaction between smoking and ATG16L1(T300A) triggers Paneth cell defects in Crohn’s disease

It is suggested that subtyping of complex inflammatory diseases can be based on genetic susceptibility and relevant environmental exposure (G+E). We propose that using matched cellular phenotypes in human subjects and corresponding preclinical models with the same G+E combinations is useful to this...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Liu, Ta-Chiang, Kern, Justin T., VanDussen, Kelli L., Xiong, Shanshan, Kaiko, Gerard E., Wilen, Craig B., Rajala, Michael W., Caruso, Roberta, Holtzman, Michael J., Gao, Feng, McGovern, Dermot P.B., Nunez, Gabriel, Head, Richard D., Stappenbeck, Thaddeus S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205411/
https://ncbi.nlm.nih.gov/pubmed/30137026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120453
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