Interaction between smoking and ATG16L1(T300A) triggers Paneth cell defects in Crohn’s disease

It is suggested that subtyping of complex inflammatory diseases can be based on genetic susceptibility and relevant environmental exposure (G+E). We propose that using matched cellular phenotypes in human subjects and corresponding preclinical models with the same G+E combinations is useful to this...

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Publicado en:J Clin Invest
Autores principales: Liu, Ta-Chiang, Kern, Justin T., VanDussen, Kelli L., Xiong, Shanshan, Kaiko, Gerard E., Wilen, Craig B., Rajala, Michael W., Caruso, Roberta, Holtzman, Michael J., Gao, Feng, McGovern, Dermot P.B., Nunez, Gabriel, Head, Richard D., Stappenbeck, Thaddeus S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205411/
https://ncbi.nlm.nih.gov/pubmed/30137026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120453
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