Western Diet Induces Paneth Cell Defects through Microbiome Alterations and Farnesoid X Receptor and Type I Interferon Activation

Intestinal Paneth cells modulate innate immunity and infection. In Crohn’s disease, genetic mutations together with environmental triggers can disable Paneth cell function. Here, we find that a Western diet (WD) similarly leads to Paneth cell dysfunction through mechanisms dependent on the microbiom...

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Pubblicato in:Cell Host Microbe
Autori principali: Liu, Ta-Chiang, Kern, Justin T., Jain, Umang, Sonnek, Naomi M., Xiong, Shanshan, Simpson, Katherine F., VanDussen, Kelli L., Winkler, Emma S., Haritunians, Talin, Malique, Atika, Lu, Qiuhe, Sasaki, Yo, Storer, Chad, Diamond, Michael S., Head, Richard D., McGovern, Dermot P.B., Stappenbeck, Thaddeus S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8192497/
https://ncbi.nlm.nih.gov/pubmed/34010595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2021.04.004
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